Pharmaceutical equipment freeze-drying machine

NegotiableUpdate on 01/07

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Nature of the Manufacturer: Producers

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Online Consult

Overview

With the advancement of modern science and technology, pharmaceutical freeze-drying machines have promoted the development of biopharmaceuticals. Traditional Chinese medicine production has moved away from the traditional "workshop" production method and widely adopted modern scientific freeze-drying technology, applying new processes, new excipients, and new pharmaceutical freeze-drying machine equipment to research and develop new dosage forms of Chinese medicine, prepare and produce new formulations, fundamentally changing the backward appearance of the pharmaceutical formulation field and improving the overall level of biopharmaceuticals. Therefore, vacuum freeze-drying technology has also been widely applied in the field of Chinese medicine.

Product Details

With the advancement of modern science and technology, pharmaceutical freeze-drying machines have promoted the development of biopharmaceuticals. Traditional Chinese medicine production has moved away from the traditional "workshop" production method and widely adopted modern scientific freeze-drying technology, applying new processes, new excipients, and new technologiesMedical freeze-drying machine equipmentBy researching and developing new dosage forms of traditional Chinese medicine, and preparing and producing new formulations, we have fundamentally changed the backward situation in the field of pharmaceutical preparations and improved the overall level of biopharmaceuticals. So vacuum freeze-drying technology has also been widely used in the field of traditional Chinese medicine.

1. Processing and preservation of traditional Chinese medicinal materials. Freeze drying technology can be used for new processing and active preservation of traditional Chinese medicinal materials.

Vacuum freeze-drying technology can effectively ensure the appearance, color, and odor of medicinal materials during application. At the same time, it also has excellent dehydration properties during application, and can reduce the decomposition and loss of active ingredients to the smallest level, ensuring the activity of medicinal ingredients themselves. Freeze drying is commonly used in the processing of medicines such as ginseng, American ginseng, winter worms, summer vegetables, and Panax notoginseng.

Taking ginseng as an example, the changes in saponin content of ginseng obtained by freeze-drying technology are not very significant under the influence of freeze-drying process conditions. Compared with fresh ginseng, the difference in sensitive components is very small. However, ginseng produced by drying has significant losses in total saponins and heat sensitivity. At the same time, the proportion of monomeric saponins also changes significantly during this process. This fully proves that freeze-drying is a relatively reasonable drying method. In the production process of Panax notoginseng, the texture of the finished product produced by freeze-drying is softer, the odor is stronger, and it is easier to cut and crush. The saponin content is 2% higher than that of Panax notoginseng produced by traditional methods, which gives it a better quality advantage.

2. Modern traditional Chinese medicine preparations.

① Chinese herbal liposomes and nanoparticles. Liquid liposomes are a type of suspension emulsion with unstable properties that are prone to aggregation, fusion, and leakage of encapsulated drugs. Liposomes can only be stored for a few weeks in liquid form, which limits their application. Freeze drying technology further expands the advantages of liposomes as drug carriers, which can be prepared and stored separately, prolong drug action time, reduce toxic side effects, and improve bioavailability.

② Freeze dried powder injection of traditional Chinese medicine. The molding and water solubility of freeze-dried powder injections made from traditional Chinese medicine formulas or prescriptions for injection are superior to traditional injection solutions, and the stability of freeze-dried powder injections is greatly improved.

③ Oral tablets of traditional Chinese medicine. Freeze drying can also be used for the preparation of oral Chinese medicine tablets.

3. Western medicine preparations.

① Western medicine liposomes. The freeze-drying technology for Western medicine preparations is relatively mature. Currently, large pharmaceutical factories in China have freeze-drying equipment, and many dosage forms (such as injections, oral preparations, eye drops, etc.) use freeze-drying technology to improve drug quality and storage life. Retinoic acid, etc.

② Western medicine freeze-dried powder injection. Western medicine is made into freeze-dried powder injections, which can prevent the drug from spoiling and are suitable for long-term storage; Easy to achieve aseptic operation; Quantitative accuracy; Good rehydration performance, such as gallic acid propylene ester, etc.

③ Other dosage forms. Oral disintegrating tablets have the advantages of convenient use, accurate dosage distribution, rapid disintegration, and minimal irritation to the digestive tract. The freeze-drying method for preparing orally disintegrating tablets not only has the above advantages, but also avoids the decomposition and deterioration of drugs due to high temperature. Moreover, due to the low water content of the product, microorganisms are not easy to grow and reproduce, making it easy to store.

4. Biopharmaceuticals. Freeze drying has been proven to be a highly effective method for addressing the chemical and physical instability of most biopharmaceuticals. Freeze drying is carried out at low temperatures and in a high vacuum state, making it particularly suitable for many heat sensitive substances; The dried substance is loose and porous, and dissolves quickly; Freeze dried products can be dehydrated and stored in vacuum or nitrogen filled packaging and away from light, with a long shelf life.